Table 1.
Neuroblastoma cell lines and their responses: MYCN status, IC50 for 5-aza-dC and differentiation status.
| Cell line | MYCN status | IC50 for 5-aza-dC (µM) |
Differentiation status | |||||
|---|---|---|---|---|---|---|---|---|
| Neurite extension | Marker gene expression*1 | |||||||
| 5-aza-dC (1 µM) | TBT (1 µM) | Combination | 5-aza-dC (1 µM) | TBT (1 µM) | Combination | |||
| NB-1 | + | 0.30 | + | + | + | + | + | + |
| NB-39-nu | + | 0.30 | + | + | + | + | + | + |
| IMR-32 | + | 0.10 | − | + | + | − | + | + |
| SH-SY5Y | − | 0.05 | NA | + | NA | _ | − | + |
| KELLY | + | 0.03 | − | + | +*2 | − | − | + |
| BE(2)-C | + | 0.11 | NA | + | NA | − | − | + |
| TGW | + | 0.07 | NA | − | NA | − | − | + |
+ indicates positive, − indicates negative. *1, + significant upreguation; − no significant upregulation. *2 0.5 µM 5-aza-dC.
NA not analysed.