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. 2021 Dec 7;12:7108. doi: 10.1038/s41467-021-27357-7

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — a–e Responses of the optimized biosensors to different concentrations of d-2-HG. a Dose-response curve of B_d2HG-1; b dose-response curve of B_d2HG-2; c dose-response curve of B_d2HG-7; d dose-response curve of B_d2HG-8; e dose-response curve of B_d2HG-12. f The linear detection range of B_d2HG-1. Black dotted line is a reference line where the reduced luminescence signal (∆RLU) is three times of the background signal. The concentrations of DhdR and Bio-dhdO mutants in a–f were 0.3 and 1 nM, respectively. Data shown are mean ± s.d. (n = 3 independent experiments). Source data are provided as a Source Data file.