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. 2021 Dec 8;8:45. doi: 10.1038/s41439-021-00172-8

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — A Clinical course. Deterioration of cirrhosis and HCC progressed with age. B Liver MRI. T2-weighted imaging detected a 2-cm tumor in the liver (S7 section). C–F Pathological tissues. The S7 tumor exhibited characteristics of well-differentiated (C) and moderately differentiated (D) HCC combined with hepatocytes with a clear cell cytoplasm (E), consistent with pathology in GSD. The S4 tumor was poorly differentiated (F) and moderately differentiated HCC. G Liver CT. Multiple HCC and ascites were detected in the abdomen.