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. 2021 Dec 7;11:23549. doi: 10.1038/s41598-021-02729-7

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Identification of differentially expressed genes by NMac1 in DNA microarray analysis. (a) Significant hierarchical clustering heatmap and (b) significant probes count of DNA microarray. (c) Significant gene mapping by KEGG pathway analysis was analyzed by STRING based on differentially expressed genes (DEGs) over 2.5-fold changes. The disconnected nodes in the network were hided. Genes colored in yellow, green, blue and red are related to stress response, AMPK pathway, mTOR pathway and MAPK pathway, respectively.