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. 2021 Nov 24;12:726504. doi: 10.3389/fmicb.2021.726504

TABLE 5.

Matrix of the central composite design and the corresponding experimental and predicted concentrations of cyclopiazonic acid produced by Penicillium commune KACC 45973.

StdOrder Run Variables
Area (mAU)
A B C Experimental Predicted
1 1 −1 −1 −1 0.00 469312.00
6 2 1 −1 1 657723.33 1344140.00
10 3 1.68179 0 0 3272122.00 3477750.00
5 4 −1 −1 1 1221872.67 1352719.00
16 5 0 0 0 3315119.33 3307446.00
15 6 0 0 0 3516230.33 3307446.00
20 7 0 0 0 4343611.00 3307446.00
19 8 0 0 0 2572035.67 3307446.00
17 9 0 0 0 4053908.33 3307446.00
3 10 −1 1 −1 862777.33 166334.00
11 11 0 −1.6818 0 296348.67 −26798.40
13 12 0 0 −1.6818 0.00 660673.00
9 13 −1.6818 0 0 0.00 −25874.20
12 14 0 1.68179 0 4334571.00 4671898.00
18 15 0 0 0 2211776.00 3307446.00
2 16 1 −1 −1 2349285.67 1599046.00
4 17 1 1 −1 4482329.00 4341456.00
7 18 −1 1 1 3691986.33 4198043.00
14 19 0 0 1.68179 4483061.00 386568.00
8 20 1 1 1 5229002.33 4984819.00
Variables Code symbol Code values
−1.68 −1 0 1 1.68
NaNO3 A 0 2 5 8 11
Tryptone B 0 2 5 8 11
Yeast extract C 0 2 5 8 11

StdOrder, standard order; mAU, milli-Absorbance Units.