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. 2021 Dec 7;11:23528. doi: 10.1038/s41598-021-02843-6

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Molecular docking of isoliquiritigenin (ILG) (blue stick) to hV_1AR (a). Close-up view of ligand binding pocket of hV_1AR in complex with ILG (b). Two-dimensional binding diagram showing interactions of ILG-hV_1AR complex (c). H-bond, pi-sigma, pi-alkyl, and pi-cation interactions are shown with green, purple, light pink, and orange dashed lines, respectively.