Table 3.

Human dopamine D₁, D₂, D₃, and D₄ and vasopressin V_1A receptor binding data of isoliquiritigenin.

Receptors	Radioligand	% Inhibition of control-specific bindinga	Reference antagonist	Reference IC50b
D1	[3H]SCH23390	96.0	SCH23390	0.5
D2L	[3H]methylspiperone	21.3	(+)Butaclamol	2.6
D3	[3H]methylspiperone	52.2	(+)Butaclamol	4.1
D4	[3H]methylspiperone	44.8	Clozapine	93
V1A*	[3H]AVP	60.8	[d(CH2)51,Tyr(Me)2]-AVP	1.4

*Agonist binding.

^aValues are presented as the mean of the percent inhibition of control specific binding by 100 µM isoliquiritigenin performed in duplicate.

^bThe IC₅₀ value of the reference antagonist (nM).