Table 6.

Prediction of the pharmacokinetic parameters and toxicity of isoliquiritigenin.

Compound	Drug-likeness	Lead-likeness	Log Po/wa	Solubilityb	HIAc	BBB permeabilityd	CNS permeabilitye	AMES toxicity	Hepatotoxicity
Isoliquiritigenin	Yes	Yes	2.37	− 3.06	91.096%	Yes (− 0.717)	− 2.205	No	No

^aOctanol-water partition coefficient.

^bLogS scale: Insoluble < − 10 < Poorly < − 6 < Moderately < − 4 < Soluble < − 2 < Very < 0 < Highly.

^cHuman intestinal absorption: If < 30%, poorly absorbed.

^dLog BB > 0.3 considered to readily cross the blood brain barrier, while log BB < − 1 considered to be poorly distributed to the brain.

^eLog PS values > − 2 are considered to penetrate the CNS, while log PS values < − 3 are considered unable to penetrate the CNS.