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. 2021 Dec 7;9:50. doi: 10.1038/s41413-021-00173-x

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 7 — The expression of target candidates in cartilage. a qPCR results showing changes in TAPT1, RIC1, and FGF20 in chondrocytes induced by siRunx1. b qPCR results showing changes in TAPT1, RIC1, and FGF20 in chondrocytes induced by Runx1 overexpression. c, d IHC staining showing AAV-Runx1 overexpression-induced changes in TAPT1 expression in articular cartilage at 12 weeks after ACLT surgery (a) and the growth plate at 24 weeks after ACLT surgery (b). e–f IHC staining showing AAV-Runx1 overexpression-induced changes in RIC1 expression in articular cartilage at 12 weeks after ACLT surgery (a) and the growth plate at 24 weeks after ACLT surgery (b). g–h IHC staining showing AAV-Runx1 overexpression-induced changes in FGF20 expression in articular cartilage at 12 weeks after ACLT surgery (a) and the growth plate at 24 weeks after ACLT surgery (b). i Optical density quantitative analysis showing changes in TAPT1 expression in articular cartilage and the growth plate. j Optical density quantitative analysis showing changes in RIC1 expression in articular cartilage and the growth plate. k Optical density quantitative analysis showing changes in FGF20 expression in articular cartilage and the growth plate. These results are based on at least three independent experiments (n = 3). All significance data presented in a, b, i, j, and k are based on two-tailed Student’s t-tests