Table 5.
Characteristics of patients with Parkinson’s disease (PD).
| Characteristics | Median (min–max) |
|---|---|
| Age (years) | 66 (59–69) |
| Sex | 9 men, 1 woman |
| Disease duration (years) | 18 (10–22) |
| Medication as l-dopa equivalent dose (mg/day) a | 416 (294–989) |
| DBS treatment duration (months) | 37 (15–70) |
| DBS pulse settings | |
| Right | |
| Amplitude (V) | 3.3 (2.5–4.3) |
| Pulse width (µs) | 60 (60–90) |
| Frequency (Hz) | 145 (100–185) |
| Left | |
| Amplitude (V) | 3.4 (2.2–4.3) |
| Pulse width (µs) | 60 (60–90) |
| Frequency (Hz) | 130 (100–185) |
| Positions of negative polarity contacts with reference to the intercommissural line midpoint | |
| Right (mm) | |
| Lateral | 11.7 (10.4–13.1) |
| Posterior | 3.4 (3.0–4.0) |
| Inferior | 2.1 (1.0–5.6) |
| Left (mm) | |
| Lateral | 11.4 (9.6–13.0) |
| Posterior | 3.5 (3.3–5.2) |
| Inferior | 2.6 (1.2–4.2) |
| Intercommissural line (mm) | 24.8 (23.5–25.6) |
| UPDRS part III scores in anti-PD medication OFF stateb | |
| DBS OFF | |
| Item 20 and 21 (tremor) | 2.3 (0–8.1) |
| Total score | 41.0 (35.0–83.5) |
| DBS ON | |
| Item 20 and 21 (tremor) | 0 (0–0) |
| Total score | 21.5 (11.0–30.5) |
| Berg balance scale in anti-PD medication OFF stateb | |
| DBS OFF | 42 (27–50) |
| DBS ON | 50 (41–52) |
| A history of falls during the past 6 months, n (%) | 7 (70%) |
aCalculated equivalent doses of Levodopa according to the method presented by Østergaard et al.49, and Calne50. All participants received L-dopa in their daily life, and 7/10 subjects received also dopamine agonists.
bUPDRS part III: Unified Parkinson’s disease Rating Scale, motor examination. The maximum total score is 108 points (higher scores = more severe motor symptoms). The Berg Balance scale has a scoring range from 0–56 points (higher scores = better). The evaluations were performed in anti-PD medication OFF state. All anti-Parkinsonian medications were withdrawn overnight for 10–12 h. The UPDRS assessments and balance assessments were done at the same occasion as the assessments of posture.