Table 5.
Hazard ratios and 95% confidence intervals for the combined effects of elevated fasting blood glucose levels, obesity, and central obesity on the risk of breast cancer in postmenopausal women who underwent a national Korean breast cancer screening program from 2009 to 2010.
| Elevated FBG | BMI (kg/m2) | High WC | No. participants | Person-years | No. cases | Adjusted HRa (95% CI) | P |
|---|---|---|---|---|---|---|---|
| No | <25 | No | 986,593 | 8,602,975.4 | 7203 | 1.00 | |
| Yes | 359,710 | 3,137,830.6 | 2356 | 1.05 (1.00–1.10) | 0.040 | ||
| ≥25 | No | 104,324 | 911,094.3 | 862 | 1.15 (1.08–1.24) | <0.001 | |
| Yes | 566,946 | 4,937,724.4 | 4699 | 1.32 (1.27–1.37) | <0.001 | ||
| Yes | <25 | No | 372,412 | 3,240,744.5 | 2741 | 1.08 (1.03–1.13) | 0.001 |
| Yes | 217,085 | 1,887,005.6 | 1449 | 1.13 (1.07–1.20) | <0.001 | ||
| ≥25 | No | 49,580 | 431,063.5 | 458 | 1.34 (1.22–1.48) | <0.001 | |
| Yes | 438,686 | 3,803,909.9 | 3816 | 1.44 (1.38–1.50) | <0.001 |
FBG fasting blood glucose, WC waist circumference.
aAdjusted for age, age at menarche, age at menopause, hormone replacement therapy use after menopause, delivery, duration of breastfeeding, oral contraceptive use, family history of any cancer, drinking frequency per week during the last 1 year, smoking, and physical activity including vigorous physical activity, moderate physical activity, and walking per week.