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. 2021 Dec 8;7:379. doi: 10.1038/s41420-021-00715-6

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — A Expression of miR-181d in DDP-resistant and DDP-sensitive OC cells in the GSE148251 dataset. B In-situ hybridization assay of the miR-181d expression in clinical tissue samples of chemo-resistant (n = 46) and chemo-sensitive (n = 32) OC patients. C CCK-8 assay evaluation of viability of A2780 and A2780/DDP cells after treatment with DDP at different concentrations (0, 10, 20, 50, 100, and 150 μmol/L) for 48 h. IC50 of A2780 = 12.72 μmol/L, and IC50 of A2780 DDP = 55.03 μmol/L. D RT-qPCR detection of miR-181d expression in A2780/DDP and A2780 cells, normalized to U6. Cell experiments were repeated three times independently. *p < 0.05 versus A2780 cells or chemo-sensitive OC patients.