Table 1.
Case characteristics. Germline BRCA1/2 (gBRCA1/2) mutations were detected in all patients after cancer diagnosis. Hematologic mutational profile was done on peripheral blood +/- bone marrow.
| BRCA status | Hematologic mutational profile | Hematologic diagnosis | PARPi maintenance | |
|---|---|---|---|---|
| Patient 1 | gBRCA1 | FLT3 A680V (VAF 49%) | Uncertain | Yes |
| Patient 2 | gBRCA1 | DNMT3A R882C (VAF 2.5%) | CHIP | No |
| Patient 3 | gBRCA2 |
TET2-G1370V (VAF 34%) TET2-L1899fs*8 (VAF 14.2%) |
CCUS | No |
VAF, variant allele frequency; CHIP, clonal hematopoiesis of indeterminate potential; CCUS, clonal cytopenias of undetermined significance