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. 2021 Dec 7;11:23548. doi: 10.1038/s41598-021-02903-x

Table 4.

Survival parameters of the 57 patients with brain metastases analyzed with NGS.

Primary tumors (n = 41)
TP53 20 (44%) 2 (40%) 2 (33%) 8 (40%) 4 (36%)
PIK3CA 9 (20%) 2 (40%) 2 (33%) 5 (22%) 5 (45%)
All (n = 52) Luminal A-like (n = 0) Luminal B-like (14) TNBC (n = 23) HER2+ (n = 15)
Brain metastases (n = 52)
TP53 25 (44%) 4 (29%) 13 (57%) 8 (53%)
PIK3CA 13 (23%) 5 (36%) 5 (22%) 3 (20%)
All (n = 37) Luminal A-like (n = 0) Luminal B-like (11) TNBC (n = 17) HER2+ (n = 9)
Concordance of mutational status in matched pairs (n = 37) 29 (67%) 7 (64%) 14/17 (82%) 7/9 (78%)