Table 3.
Roles of GV in cognitive impairment.
| Metrics of GV | Individuals | Results | References |
|---|---|---|---|
| MAGE | 121 T2DM patients | Significantly correlated with cognitive impairment | 76 |
| Multi-Scale GV | 43 older adults with and 26 without T2DM | Might contribute to brain atrophy and cognitive impairment | 77 |
| SD and CV of visit-to-visit HbA1c | 68 T2DM patients | Visit-to-visit GV influenced cognitive impairment | 78 |
| SD of HbA1c | 124 T2DM patients | Significantly associated with white matter hyperintensitie | 80 |
| Glycoalbumin/HbA1c | 178 elderly patients with diabetes | Independently associated with white matter hyperintensitie | 82 |
| SD and MAGE of HbA1c | 40 patients with AD-related diabetes and 19 patients with diabetes-related dementia | GV is more involved in the pathophysiology of diabetes-related dementia than Alzheimer’s disease associated with diabetes | 83 |
CV coefficient of variation, SD standard deviation, T2DM type 2 diabetes mellitus, HbA1c hemoglobin A1c, MAGE mean amplitude of glycemic excursion.