Table 4.

The difference of efficacy, according to LDH—elevated LDH at baseline, 16 and 32 weeks showed inadequate treatment response in EASI.

	LDH at baseline		LDH at 16 weeks		LDH at 32 weeks		LDH at 52 weeks
	< 250 (n = 30)	≥ 250 (n = 43)	< 250 (n = 66)	≥ 250 (n = 22)	< 250 (n = 63)	≥ 250 (n = 21)	< 250 (n = 65)	≥ 250 (n = 6)
Percent change of EASI after 52 weeks	90.50	85.55	89.42	84.49	90.75	82.49	89.32	78.60
p value*		0.014		0.046		< 0.001		0.052
Percent change of NRS after 52 weeks	70.29	62.63	68.36	57.69	70.46	59.37	69.18	47.22
p value*		0.194		0.067		0.052		0.003
Percent change of POEM after 52 weeks	67.62	66.85	68.76	67.10	71.22	68.06	70.87	36.13
p value*		0.920		0.793		0.576		< 0.001
Percent change of DLQI after 52 weeks	72.78	65.38	70.22	63.33	74.16	61.82	73.49	46.98
p value*		0.315		0.260		0.058		0.013

*p values were obtained by two sample independent t-test.