TABLE 1.
List of studies comparing standard treatment or chemotherapy and combination therapy with stem cell therapy.
| Study author and year published | Cancer type | Treatment | Significant findings |
| Stadtmauer et al. (2000) | Metastatic breast cancer | Maintenance verse high-dose chemotherapy and autologous SC transplantation | The study found no difference between the two groups’ outcomes. |
| Farquhar et al. (2005, 2016) | Breast cancer | Conventional verse high dose chemotherapy and BMSC/PSC autologous transplantation | The study found little to no difference between the two groups’ outcomes. |
| Namouni et al. (1997) | Retinoblastoma | Maintenance vs. high-dose chemotherapy and carboplatin, etoposide and cyclophosphamide and hematopoietic SC rescue | The study found improved outcomes in patients with interventional treatment at a 3-year survival disease-free time point. Patients that have co-occurring CNS disease did not have improved outcomes. |
| Motzer et al. (2007) | Metastatic germ cell tumors | Standard chemotherapy dose vs. high-dose chemotherapy and autologous hematopoietic SC | The study found no difference between the two groups’ outcomes. |
| Graham et al. (1997) | High-risk and recurrent pediatric brain tumors | Standard vs. high-dose chemotherapy and autologous marrow rescue with or without peripheral-blood SC | Interventional treatment shows it might improve outcomes. |
| Yalçin et al. (2015) | High−risk pediatric neuroblastoma | High−dose chemotherapy and autologous hematopoietic stem cell rescue | The study found no difference between the two groups outcomes. |
| Berry et al. (2011) | Breast cancer | High-dose chemotherapy and autologous hematopoietic stem cell transplantation | The study found improved outcomes in patients with high |
| Delaye et al. (2021) | Germ cell tumor with brain metastases | High-dose chemotherapy followed by infusions of autologous peripheral blood hematopoietic stem cells | The study found improved overall survival at 12 months. |
| Ferreri et al. (2017) | Primary CNS lymphoma | High-dose methotrexate-based chemotherapy followed by autologous peripheral blood stem-cell transplantation following | The study found the therapy effective at 2-year progression-free survival |
| Illerhaus et al. (2016) | Primary CNS lymphoma | High-dose methotrexate-based chemotherapy with autologous stem cell transplantation | The study found a complete response 30-days post treatment |