Table 3.
Heritability Estimates.
| Phenotype Definition | Unadjusted | Adjusted⁑ | HIV-Onlyǂ |
|---|---|---|---|
| Active TB vs. LTBI and “no active TB”* | 28.7% | 37.1% | 38.7% |
| TB vs. LTBI | 56.0% | 56.4% | 55.2% |
| RSTR vs. LTBI | 50.9% | 48.3% | 50.4% |
| RSTR vs. LTBI and Active TB | 45.2% | 45.2% | 45.8% |
⁎
“no active TB” refers to both RSTRs and subjects who did not have long-term follow up data including IGRA. This includes subjects who were TST+ or TST- during the original study, but could not be categorized without IGRA and long-term data and are referred to as “no active TB” earlier in the document.
⁑
“adjusted” refers to estimates that were adjusted for age, sex, and HIV status. For the RSTR vs. LTBI, the age at which they were distinguished as RSTR or LTBI in a sub-study was used. For the other estimates, the age at first presentation was used.
ǂ
These estimates only included the HIV- subjects and were adjusted for age and sex