Table 4.
ΑDR-α antagonists.
| Subtype | Drug | Material basis | Model | Effect | Mechanism | References |
|---|---|---|---|---|---|---|
| ΑDR-α1 antagonists | Doxazosin | 8 | MDA-MB-231 MCF-7 MCF12A |
Induced apoptosis | Blocked EGFR and NF-κB signaling | [63] |
| ΑDR-α2 antagonists | Rauwolscine | 9 | MC4-L5 Mouse tumor C4-HD |
Inhibited the proliferation | [145] | |
| Yohimbine | 10 | MCF-7 SCID mice |
Reversed cell proliferation induced by clonidine | Enhanced the pump function of P-glycoprotein and confers resistance of MCF-7 cells to paclitaxel | [139] | |
| Tramadol | 11 | MDA-MB-231 BALB/c mice |
Inhibited proliferation, migration, and invasion | Reduced ERK expression | [153] |