Table 5.
ΑDR-β2 antagonists.
| Subtype | Drug | Material basis | Breast cancer cell line | Effect | Mechanism | References |
|---|---|---|---|---|---|---|
| Natural products that inhibit ADR-β2 | Quercetin-3-O-glucuronide (Q3G) | 13 | MDA-MB-231 | Suppressed cell invasion and MMP-9 induction and inhibited the binding of [3H]-NA to ADR-β2 | Suppressed ROS generation, cAMP and RAS activation, phosphorylation of ERK1/2, and HMOX1, MMP2, and MMP9 gene expression | [155] |
| ADR-β2 antagonists | Propranolol | 12 | MDA-MB-435 MDA-MB-231 |
Inhibited the viability of cells, arrested cell cycle progression at G0/G1 and S phase, and induced cell apoptosis | ERK1/2 and COX-2 phosphorylation levels were significantly decreased after β-blocker treatment. | [154] |
| ICI 118,551 | 14 | MDA-MB-48 | ||||
| Atenolo | 15 | MDA-MB-453 | Inhibited cell proliferation | [21] | ||
| Isoproterenol | 16 | MDA-MB-231 ZR-75 |
Inhibited cell proliferation | Inhibited DNA synthesis | [129] |