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. 2021 Nov 24;8:784681. doi: 10.3389/fnut.2021.784681

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Copyright © 2021 Liu, Zhong, Luo, Ma, Liu and Wang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The effects of intermittent fasting and melatonin supplementation on intestinal metabolites in mice. (A) Score plot from and PLS-DA of metabolite profiles of the intestinal contents of mice between all groups. Each data point represents a function of the entire spectral profile of each subject; (B) The permutation test was evaluated based on the corresponding PLS-DA model. (C) A heatmap of significantly altered metabolites in the intestines of mice between all groups. (D) Metabolic pathways related to each metabolite. Data are presented as mean ± SEM, n = 12. C, control; F, intermittent fasting; M, melatonin; MF, intermittent fasting plus melatonin. The C and M mice were fed ad libitum, while the F and MF groups underwent alternative-day feed deprivation. The M and MF groups mice were supplemented with melatonin at a dose of 10 mg/kg body weight by drinking.