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. 2021 Nov 24;8:760203. doi: 10.3389/fcvm.2021.760203

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Copyright © 2021 Tavoian, Ramos-Barrera, Craighead, Seals, Bedrick, Alpert, Mashaqi and Bailey.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Detailed overview of the CHART study protocol. 6MW, six-minute walk; AHI, apnea hypopnea index; BMI, body mass index; BP, blood pressure; CHAMPS, Community Healthy Activities Model Program for Seniors physical activity questionnaire; ESS, Epworth Sleepiness Scale; FMD_BA, brachial artery flow-mediated dilation; HR, heart rate; IMST, inspiratory muscle strength training; PI_max, maximal inspiratory pressure; PNE, plasma norepinephrine; PSQI, Pittsburgh Sleep Quality Index; PWV_CF, carotid-femoral pulse wave velocity; SBP, systolic blood pressure; *Indicates PWV_CF and FMD_BA will be performed with saline and Vitamin C infusion. ^†The following surveys will be completed at home: CHAMPS, ESS, PSQI.