. 2021 Nov 24;8:760203. doi: 10.3389/fcvm.2021.760203

Table 2.

Schedule of events.

	Baseline		Exercise intervention				Post		F4 and F12
	V1	V2	Wk 1	Wks 2–4	Wks 6–22	Wk 23	V1	V2	V1	V2
Day (window)	−14–0		1–7	8–28	29–154	147-154	168–182		F4: 203–217 F12: 259–273
Screening/baseline
Informed consent	X
Demographics	X
Medical Hx/physical exam	X
Inclusion/exclusion	X
Height/weight	X						X		X
Vitals	X	X	X	X	X	X	X	X	X	X
Neck circumference	X						X		X
Cognitive assessments
NIH Toolbox			X			X
Surveys
CHAMPS	X						X		X
PSQI	X						X		X
ESS	X						X		X
Exercise sessions
Daily exercise			X	X	X	X
Once-weekly supervised			X	X
Twice-monthly supervised					X	X
Weekly text/email			X	X	X	X
At-home testing
24-h BP		X				X			X
HSAT	X						X
Actigraphy			X			X
Sleep/exercise diary			X	X	X	X
Functional assessments
Casual BP		X						X		X
Spirometry	X						X		X
PI_max			X	X	X	X	X		X
6MW	X						X		X
Grip strength	X						X		X
Blood draws
PNE		X						X		X
Blood chemistries		X						X		X
Arterial assessments
PWV_CF	X						X		X
PWV_CF with NS		X						X		X
FMD_BA	X						X		X
FMD_BA with NS		X						X		X
FMD_BA with vitamin C		X						X		X
EID with SL NTG		X						X		X
Randomization		X

6MW, six-minute walk; CHAMPS, Community Health Activities Model Program for Seniors physical activity questionnaire; BP, blood pressure; EID, endothelium-independent dilation; ESS, Epworth Sleepiness Scale; F4, first follow-up at 4 weeks; F12, second follow-up at 12 weeks; FMD_BA, brachial artery flow-mediated dilation; HSAT, home sleep apnea testing; Hx, history; NS, normal saline infusion; NTG, nitroglycerin; PI_max, maximal inspiratory pressure; PNE, plasma norepinephrine; PSQI, Pittsburgh Sleep Quality Index; PWV_CF, carotid-femoral pulse wave velocity; SL, sublingual; V, visit. ^†Surveys completed at home: CHAMPS, PSQI, ESS.