Table 3.

Outcome assessments and internal controls.

Outcome assessments	Internal controls
• Casual BP • 24-h BP monitoring • Blood draw • EDD via FMDBA (with and without systemic saline and vitamin C infusion) • EID via sublingual nitroglycerin • Arterial stiffness via PWVCF • 6MW • NIH Toolbox—cognitive domain • PImax • Resting heart rate • Home sleep apnea testing • Grip strength • MSNA (subset of participants)	• Anthropometrics • Surveys • PSQI • ESS • CHAMPS • Actigraphy • Spirometry • Sleep and physical activity diaries

Outcome Assessments include primary, secondary, and other outcomes of interest in the CHART study. Internal Controls will be completed to determine consistency of behavior throughout the study and to account for unreported changes. See Supplementary Material for protocols related to Internal Controls. 6MW, six-minute walk distance; BP, blood pressure; CHAMPS, Community Healthy Activities Model Program for Seniors physical activity questionnaire; EDD, endothelial-dependent dilation; EID, endothelial independent dilation; ESS, Epworth Sleepiness Scale; FMD_BA, brachial artery flow-mediated dilation; PI_max, maximal inspiratory pressure; PSQI, Pittsburgh Sleep Quality Index; PWV_CF, carotid-femoral pulse wave velocity.