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. 2021 Nov 24;9:719993. doi: 10.3389/fcell.2021.719993

FIGURE 4.

FIGURE 4

ADAMTS9-AS1 promotes TGFBR2 through miR-301b-3p to inhibit breast cancer cell invasion and proliferation. (A) The proliferation of MCF-7 cells. (B) EdU assay used to detect MCF-7 cell proliferation (400×). (C) Invasion of MCF-7 cells (100×). (D) Levels of Ki67, PCNA, MMP-2 and MMP-9. (E) Level of TGFBR2 in si-NC, si-TGFBR2-1 and si-TGFBR2-2 groups. The silencing sequence with the highest silencing efficiency was named as si-TGFBR2. (F) ADAMTS9-AS1 and TGFBR2 expression in MDA-MB-231 cells. (G) Proliferation of MDA-MB-231. (H) Proliferation of MDA-MB-231 (400×). (I) Cancer cell invasion (100×). (J) Levels of Ki67, PCNA, MMP-2 and MMP-9. *p < 0.05.