Table 3. Performance of APRI and FIB-4 against METAVIR score for different cut-off values proposed by the WHO HBV guidelines.
WHO HBV guidelines [21]
APRI: aspartate aminotransferase-to-platelet ratio Index, FIB-4: fibrosis index based on four factors; METAVIR: Meta-analysis of Histological Data in Viral Hepatitis; HBV: hepatitis B virus
| Cut off values suggested by most of the Authors | ≥F2 | Cirrhosis (F4) | |||
| Sensitivity (95% CI) | Specificity (95% CI) | Sensitivity (95% CI) | Specificity (95% CI) | ||
| APRI | Lower cut-off (0.5 for ≥F2 and 1 for F4) | 82% (77-86) | 57% (49-65) | 77% (73-81) | 78% (74-81) |
| Higher cut-off (1.5 for ≥F2 and 2 for F4) | 39% (32-47) | 92% (89-94) | 48% (41-56) | 94%(91-95) | |
| FIB-4 | Lower cut-off (1.45 for ≥F2) | 89% (79-95) | 42% (25-61) | - | - |
| Higher cut-off (3.25 ≥F2) | 59% (43-73) | 74% (56-87) | - | - | |