FIGURE 6.

MIC of trimethoprim under conditions of exogenous purine metabolites and overexpressed AcrAB. (A) The concentrations of exogenous products are 1 mM for adenosine, guanosine, and adenosine triphosphate, and ATP. Equal volume of ddH₂O was added as a control group (B). Expression of key genes in the efflux pump. The rpkm of three acrR copies was presented separately. (C) MIC of trimethoprim to Aeromonas veronii overexpressing acrAB. * represents p < 0.05, ^** represents p < 0.01, and ns represents no significant difference.