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. 2021 Nov 24;12:786602. doi: 10.3389/fimmu.2021.786602

Figure 1.

Figure 1

Mice lacking Fpr2 are highly susceptible to GBS infection. (A) Survival of WT or Fpr2-deficient mice after i.p. challenge with 2×108 CFU/ml of GBS; each included 10 animals per group. The survival rates of the two groups were compared using a log-rank test. (B, C) Numbers of bacterial in peripheral blood and peritoneal lavage fluid of WT or Fpr2-deficient mice at 3h, 6h, 24h after i.p. challenge with 2×108 CFU/ml of GBS. Each was conducted on a different animal over the course of two experiments, each of which included 6-8 animals per group. (D) Survival of WT or Fpr2-deficient mice after i.v. challenge with 2×108 CFU/ml of GBS, each of which involved 10 animals per group. The survival rates of the two groups were compared using a log-rank test. (E) Numbers of bacterial in peripheral blood of WT or Fpr2-deficient mice at 3h, 6h, 24h after i.v. challenge with 2×108 CFU/ml of GBS. Each was conducted on a different animal, with 6-8 animals per group. (F) Numbers of bacterial in brain, spleen, liver and kidney of WT or Fpr2-/- mice at 24h. (G) Hematoxylin and eosin staining of infected tissue sections at 24 h of infection. The horizontal line indicates 200 microns. (H) Clinical scoring was performed in accordance with a formerly developed scoring list for a bacterial mouse model. Data are shown as mean ± SD. *P < 0.05, **P < 0.01, ***P < 0.001, ns means non sense.