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. 2021 Nov 24;12:727532. doi: 10.3389/fgene.2021.727532

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Copyright © 2021 Li, Bushel, Lin, Day, Wang, DeMayo, Wu and Li.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The SEMIPs user interface. The main panel contains four tabs: “T-Scores”, “Bootstrap”, “SEM”, and “Instructions”. The right panel shows the screen when the “T-Scores” tab is selected and generated. In the left panel, the application accepts two inputs: 1) a list of signatures (in Entrez gene symbol format) and 2) a data matrix of expression measurement with the top lines shown for viewing. The green “Go!” button is clicked to launch the T-score generation and grayed out to denote the process is running. The first 10 rows of the T-scores matrix are shown; however, the entire matrix can be downloaded by clicking the “Download T-Scores” button.