Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Pathogenesis of liver fibrosis. The release of damage-related patterns (DAMPs). and apoptotic bodies can be induced by chronic hepatocyte injury, which activates hematopoietic stem cells and recruits immune cells. Moreover, the complex multidirectional interaction between activated hematopoietic stem cells and Kupffer cells and innate immune cells promotes transformation and differentiation into proliferation and ECM to generate myofibroblasts.
