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The mechanism of ceRNA. (A) In the cytoplasm, miRNAs could regulate 3′- UTR of mRNAs through base pairing with partial complementarity in the conventional crosstalk of RNA transcripts, thus inhibiting mRNAs. (B) Under the ceRNA mechanism of cancer cells, miRNAs are isolated from each other by abnormally expressed lncrna and MREs, thus reducing the interaction between miRNA and mRNA, thereby weakening the inhibition of downstream mRNA.
