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. 2021 Nov 24;12:779606. doi: 10.3389/fphar.2021.779606

FIGURE 4.

FIGURE 4

The mechanism of lncRNA to liver fibrosis. Multiple stimuli such as chronic hepatitis B (CHB) damage hepatocytes to initiate wound healing responses, and LncRNAs play a role in promoting activation and apoptosis of hepatic stellate cells and inducing epithelial-mesenchymal transition (EMT) at multiple stages, leading to excessive accumulation of extracellular matrix (ECM) proteins in hepatocytes, resulting in liver fibrosis generation and progression.