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. 2021 Nov 24;9:778015. doi: 10.3389/fcell.2021.778015

FIGURE 1.

FIGURE 1

The effect of bone-derived factors on brain at all stages. OCN affects the development of fetal hippocampus through fetal blood, and the GPR158 receptors that acted on adults affects the synthesis of neurotransmitters. For elderly, OPN affects inflammatory plaques and promotes the remyelination and formation of AD patients. Improve the function of the blood-brain barrier in patients with acute brain injury.