TABLE 1.
GO term analysis for AS-NMD regulated genes in humans.
| GOTerm | Adjusted p-value | Number of genes |
|---|---|---|
| Metal ion binding | 0.0002 | 1,328 |
| Nucleotide binding | 0.0000 | 766 |
| Ribonucleotide binding | 0.0000 | 675 |
| Purine nucleotide binding | 0.0000 | 670 |
| Purine ribonucleotide binding | 0.0000 | 668 |
| Purine ribonucleoside triphosphate binding | 0.0000 | 640 |
| RNA binding | 0.0000 | 584 |
| Adenyl nucleotide binding | 0.0000 | 558 |
| Adenyl ribonucleotide binding | 0.0000 | 556 |
| ATP binding | 0.0000 | 534 |
| Hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides | 0.0000 | 493 |
| Pyrophosphatase activity | 0.0000 | 490 |
| Nucleoside-triphosphatase activity | 0.0000 | 471 |
| ATPase activity | 0.0000 | 203 |
| GTPase binding | 0.0019 | 197 |
| Nucleoside-triphosphatase regulator activity | 0.0014 | 130 |
| mRNA binding | 0.0000 | 121 |
| GTPase regulator activity | 0.0014 | 117 |
| GTPase activator activity | 0.0014 | 104 |
| Methyltransferase activity | 0.0000 | 94 |
| Nuclease activity | 0.0026 | 90 |
| Helicase activity | 0.0000 | 84 |
| Nucleotidyltransferase activity | 0.0022 | 76 |
| S-adenosylmethionine-dependent methyltransferase activity | 0.0000 | 71 |
| DNA-dependent ATPase activity | 0.0000 | 57 |
| Single-stranded DNA binding | 0.0008 | 54 |
| Exopeptidase activity | 0.0022 | 51 |
| N-methyltransferase activity | 0.0000 | 47 |
| Exonuclease activity | 0.0026 | 46 |
| DNA helicase activity | 0.0000 | 45 |
| Single-stranded RNA binding | 0.0001 | 43 |
| Hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides | 0.0018 | 41 |
| RNA helicase activity | 0.0000 | 41 |
| Protein methyltransferase activity | 0.0000 | 39 |
| 3′-5′ exonuclease activity | 0.0026 | 32 |
| Exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5′-phosphomonoesters | 0.0026 | 31 |
| NAD binding | 0.0014 | 30 |
| Aminopeptidase activity | 0.0022 | 25 |
| Polyubiquitin modification-dependent protein binding | 0.0037 | 24 |
| 2-oxoglutarate-dependent dioxygenase activity | 0.0026 | 23 |
| Aminoacyl-tRNA ligase activity | 0.0026 | 22 |
| 5′-3′ RNA polymerase activity | 0.0022 | 22 |
| Exoribonuclease activity | 0.0026 | 22 |
| Pre-mRNA binding | 0.0019 | 20 |
| Ran GTPase binding | 0.0019 | 20 |
| Positive regulation of telomerase activity | 0.0026 | 19 |
| 3′-5′-exoribonuclease activity | 0.0026 | 19 |
| Mannosyltransferase activity | 0.0007 | 18 |
| NF-kappaB binding | 0.0025 | 17 |
| Poly-pyrimidine tract binding | 0.0001 | 16 |
| Poly-purine tract binding | 0.0001 | 16 |
| Telomerase RNA binding | 0.0015 | 15 |
| Phosphotransferase activity, for other substituted phosphate groups | 0.0015 | 15 |
| Prenyltransferase activity | 0.0015 | 13 |
| Poly(A) binding | 0.0001 | 13 |
| Mismatched DNA binding | 0.0026 | 10 |
| Acyl-CoA dehydrogenase activity | 0.0027 | 8 |
| Protein-arginine N-methyltransferase activity | 0.0027 | 8 |
| Protein prenyltransferase activity | 0.0015 | 7 |
| Protein-arginine omega-N symmetric methyltransferase activity | 0.0027 | 5 |