Table 1.
Basic information of the included preclinical experiments.
| ID | Animal species | Gender | Number of animals | Age | Weight | Intervention | Experimental duration | Experimental type |
|---|---|---|---|---|---|---|---|---|
| Luo X P 1999 | SD rats (NR) | Male | 49 | NR | 250-300 g | SBP | 14 days | Pharmacodynamics |
| Xiang L 2013 | SD rats (NR) | Male | 56 | NR | 200 ± 20 g | SBP, SFSBP, seven components∗ | 15 days | Metabonomics |
| Liu Q 2017 | SD rats (SPF) | Male | 81 | NR | 200 ± 20 g | Ginsenosides in SBP | 5 days | Metabonomics |
| Jiang P 2011 | SD rats (NR) | Male | 17 | NR | 200 ± 15 g | SBP | 4 days | Metabonomics |
| Yu F 2021 | SD rats (SPF) | Male | 6 | 7 weeks | 200-230 g | SBP | 15 days | Quantitative proteomics |
Note: SD: Sprague-Dawley; SPF: specific pathogen-free; SBP: Shexiang Baoxin Pill; SFSBP: simplified formula of SBP; NR: not reported. ∗Including muskone, ginsenoside, ginsenoside, cinnamic acid, cholic acid, bufalin, and borneol.