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. 2021 Nov 24;12:752233. doi: 10.3389/fimmu.2021.752233

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Copyright © 2021 Ali, Alterki, Sindhu, Alahmad, Hammad, Al-Sabah, Alghounaim, Jamal, Aldei, Mairza, Husain, Deverajan, Ahmad, Cherian, Alkhairi, Alkandari, Abubaker, Abu-Farha and Al-Mulla

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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SARS-CoV2 IgG (A–E) and neutralizing antibodies (F–J) decline over time since receiving the second dose of BNT162b2 (Pfizer–BioNTech) vaccine stratified by diabetes and hypertension status. The smooth relationships were derived from generalized additive models with penalized splines for duration (in days) and adjusted for age, gender, BMI, hypertension, diabetes status, comorbidity scores, and previous COVID-19 infections. Solid lines represent the effect estimates of change over time, while the shaded areas represent the 95% confidence intervals.