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. 2021 Nov 24;8:739607. doi: 10.3389/fnut.2021.739607

Table 3.

Bone parameters (μCT) in male Sprague-Dawley rats after 24 or 74 days.

Whey 24 d Soy 24 d p -value Whey 74 d Soy 74 d p -value
(n = 6) (n = 6) (n = 7) (n = 8)
Soy vs. Whey Soy vs. Whey
(A) Full humerus length (mm) 22.55 ± 0.38 23.55 ± 0.37 0.001 28.37 ± 0.75 28.59 ± 0.37 0.49
% BV/TV 70 ± 6 65 ± 5 0.14 71 ± 1 66 ± 1 0.002
Volumetric bone mineral density (vBMD) [mg HA/ccm] 354.57 ± 74.48 367.73 ± 56.58 0.74 651.98 ± 19.22 586.08 ± 37.53 0.011
(B) Cortical bone parameters
Tt.Ar (mm2) 3.88 ± 0.23 4.46 ± 0.38 0.012 6.04 ± 0.50 5.85 ± 0.58 0.49
Ct.Ar (mm2) 2.46 ± 0.63 2.99 ± 0.47 0.13 4.7 ± 0.33 4.19 ± 0.36 0.017
Ct.Ar/Tt.Ar 0.63 ± 0.14 0.67 ± 0.09 0.56 0.78 ± 0.03 0.72 ± 0.02 0.001
Ct.Th (mm) 0.4 ± 0.16 0.47 ± 0.12 0.39 0.65 ± 0.02 0.59 ± 0.04 0.007
Dia.Dia (mm) 2.22 ± 0.07 2.38 ± 0.10 0.01 2.77 ± 0.11 2.73 ± 0.14 0.49
Med.Dia (mm) 1.33 ± 0.23 1.36 ± 0.18 0.80 1.3 ± 0.12 1.45 ± 0.11 0.03
(B1) MOI parameters
I min (mm4) 0.9 ± 0.21 1.26 ± 0.28 0.03 2.49 ± 0.43 2.2 ± 0.34 0.15
Polar (mm4) 2.06 ± 0.45 2.88 ± 0.58 0.02 5.77 ± 0.86 5.26 ± 1 0.3
Areal (mm3) 0.87 ± 0.18 1.12 ± 0.15 0.03 1.82 ± 0.20 1.73 ± 0.21 0.41
(C) Trabecular bone parameters
Tb.BV/TV 0.23 ± 0.13 0.25 ± 0.07 0.72 0.25 ± 0.06 0.22 ± 0.03 0.27
Tb.Th (mm) 0.1 ± 0.03 0.11 ± 0.01 0.84 0.1 ± 0.01 0.11 ± 0.004 0.35
Tb.N (mm−1) 1.79 ± 0.49 1.93 ± 0.25 0.56 1.88 ± 0.83 1.62 ± 0.37 0.46
Tb.Sp (mm) 0.65 ± 0.12 0.60 ± 0.06 0.37 0.68 ± 0.27 0.72 ± 0.15 0.75

All values are mean ± SD. Bone length and cortical thickness and BV/TV of the distal bone were significantly different between the two diets. BV/TV, Bone volume/total volume; vBMD, bone volumetric bone mineral density; Tt.Ar, total area; Ct.Ar, cortical area; Ct.Ar/Tt.Ar, cortical area fraction; Ct.Th, cortical thickness; Dia.Dia, diaphyseal diameter; Med. Dia, medullary diameter; MOI, moment of inertia; I min, Minimum moment of inertia; Tb. Th, trabecular thickness; Tb.N, trabecular number; Tb.Sp, trabecular separation.