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. 2021 Nov 24;13:705594. doi: 10.3389/fnagi.2021.705594

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Copyright © 2021 Zhan, Hakoupian, Jin and Sharp.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Double immunostaining of LPS and microglial Iba1 in the PVWM of AD and aging control brains. (A) LPS (A2) and Iba1 (A3) in control PVWM did not co-localize (A1). Iba1 stained microglia were sparse (A1,A3). (B) LPS (B2) and Iba1 (B3) in AD PVWM did not co-localize (B1). Iba1 stained microglia were sparse in AD PVWM (B1,B3). Note: MDZ, myelin deficient zone; V, ventricle; LPS, lipopolysaccharide; Iba1, microglial marker; AD, Alzheimer's Disease; Bar = 50 μm.