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Effects of SHO and GIN on antigen-induced β-hexosaminidase release in the RBL-2H3 cell line. RBL-2H3 cells were sensitized with monoclonal anti-dinitrophenyl mouse IgE, and degranulation was induced. Cells were treated with 0 nM (OVA group treated with DMSO), 10, 25, 50 and 100 nM (A) SHO or (B) GIN. OVA value was used to determine maximum response (100%). Values are presented as mean ± SD. **P<0.01, ***P<0.001 vs. OVA group. OVA, ovalbumin; SHO, 6-shogaol; GIN, 6-gingerol.
