Table 2.

Key antipsychotic targets + associated drug benefit and AE impact examples.

Target	Clinical effects associated with antagonism or partial agonism
	Desired	Adverse effects (AE)
D2(*)	Antipsychotic (positive symptoms)	EPS, prolactin ↑, sexual dysfunction and cognition ↓
D3*	Antipsychotic (negative symptoms)
5-HT1A*	Anxiolytic, antidepressant, anti-EPS(?)
5-HT2A	Anti-EPS and –akathisia
5-HT2C		Appetite/weight ↑ and metabolic effects
H1	Sedation	Sedation, cognition ↓, appetite/ weight ↑
Alpha1		Hypotension, sexual dysfunction
Muscarinic	Anti-EPS	Dry mouth, constipation, blurry vision, cognition ↓

^* Partial agonism

^(*)Antagonism (Desired and Adverse Effects) or partial agonism (only Desired).