Table 3.

Examples of commonly used antipsychotics, their t_1/2, and main metabolic enzymes.

Drug	Approximate t1/2, h	CYP subtype
Haloperidol (HAL)	21	3A4 (2D6)
Olanzapine (OLA)	33	1A2 (2D6)
Clozapine (CLZ)	12	1A2, 3A4, 2C19, (2D6)
Risperidone (RIS)	3 (~20; 9-OH)*	2D6, 3A4
Quetiapine (QUE)	6-7	3A4 (2D6)
Aripiprazole (ARI)	70	3A4, 2D6
Cariprazine (CAR)	70 (~400; DDC)†	3A4 (2D6)

Data extracted from corresponding drug SPC's and the literature [see, i.a., (25)].

^*t_1/2 of active metabolite to RIS; 9-OH-RIS = paliperidone (PAL).

^†t_1/2 of active metabolite to CAR; DDC = di-desmethyl-CAR.