Table 4.

Summary of theoretical pharmacological usefulness of APP examples discussed.

Overall rating	APP combination	Comments
Fine	CLZ + CAR	Complementary PD and PK profiles—potential for improved efficacy as well as AE outcome + short- and long-acting agent combination (contributing to compliance)
	CLZ + ARI
	OLA + CAR
	QUE + CAR
Conceivable, but possible issues	RIS + CAR HAL + CAR	Some potential for improvement, but complex PD interaction—challenging to optimize doses for efficacy and AE benefits
	CLZ + RIS OLA + RIS	Doubtful efficacy improvement; increased AE burden
Futile	CLZ + QUE	PK as well as PD profile overlap
	ARI + CAR