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Summary of putative clinical impact of APP treatment involving partial agonists.
| Issue | Type | Putative clinical impact (target/s) |
|---|---|---|
| Positive symptoms | Desired | Improvement (partial D2) |
| Negative symptoms | Desired | Improvement (partial D3) |
| Hyperprolactinaemia (RIS, HAL, PAL) | AE | Attenuation (partial D2) |
| Weight/metabolic (e.g., OLA, CLZ) | AE | Improvement (interaction partial D2 vs. H1/5-HT2C?) |
| Sedation (e.g., OLA, RIS) | AE | Improvement (interaction partial D2 vs. H1?) |
