Figure 1.

Schematics for the use of MSRs for vaccination. MSRs are loaded with a recruiting factor, adjuvant, and antigen by adsorption, before being lyophilized. The vaccine can be stored in powder form until ready to be administered. After reconstitution in an aqueous buffer, MSR vaccine can be injected subcutaneously and create a scaffold for DC recruitment and homing, allowing their local activation and antigen presentation. Recruited and activated DCs migrate to the draining lymph node where they participate in the generation of an adaptive immune response against the desired antigens by priming cognate T‐cells. B‐cell, activation, in conjunction with DC‐induced CD4⁺ T cells participate in the generation of antigen‐specific B‐cell response.