TABLE 2.
Preterm birth in pregnancies with and without SARS‐CoV‐2 infection, stratified by race and ethnicity—seven New York Hospitals, March 15 to June 28, 2021 a
| Outcome | SARS‐CoV‐2 infection status at delivery, N (%) b | p value e | Resolved prenatal SARS‐CoV‐2 infection status, N (%) c | p value e | |||
|---|---|---|---|---|---|---|---|
| Symptomatic Positive d (n = 268) | Asymptomatic Positive (n = 993) | Negative (n = 30 289) | Positive (n = 1212) | Negative (n = 8440) | |||
| Preterm birth | 51 (19.0) | 87 (8.8) | 2140 (7.1) | <0.001 | 73 (6.0) | 505 (6.0) | 0.96 |
| Non‐Hispanic White | 13/80 (16.3) | 24/367 (6.5) | 720/13 482 (5.3) | <0.001 | 14/383 (3.7) | 189/4102 (4.6) | 0.39 |
| Non‐Hispanic Black | 8/37 (21.6) | 14/119 (11.8) | 437/3688 (11.8) | 0.19 | 25/191 (13.1) | 85/872 (9.7) | 0.17 |
| Hispanic | 17/89 (19.1) | 23/298 (7.7) | 433/5489 (7.9) | <0.001 | 20/391 (5.1) | 92/1352 (6.8) | 0.23 |
| Other race/ethnicity | 13/62 (21.0) | 26/209 (12.4) | 550/7630 (7.2) | <0.001 | 14/247 (5.7) | 139/2114 (6.6) | 0.58 |
| Spontaneous preterm birth f | 14/231 (6.1) | 49/955 (5.1) | 1196/29 345 (4.1) | 0.09 | 36/1175 (3.1) | 299/8234 (3.6) | 0.33 |
| Medically indicated preterm birth g | 37/254 (14.6) | 38/944 (4.0) | 944/29 093 (3.2) | <0.001 | 37/1176 (3.1) | 206/8141 (2.5) | 0.22 |
Abbreviations: PCR, polymerase chain reaction; SARS‐CoV‐2, severe acute respiratory syndrome coronavirus 2.
Self‐reported race and ethnicity data were collected from prespecified categories on hospitalization.
Infection at delivery is based on positive SARS‐CoV‐2 PCR testing during delivery hospitalization.
Resolved prenatal SARS‐CoV‐2 infection is based on negative PCR testing at delivery and either positive immunoglobulin G antibody testing (n = 1112) or previous positive PCR testing (n = 100). Negative for resolved prenatal infection is based on negative antibody testing at delivery (n = 8440).
Symptomatic patients met criteria for mild, moderate, severe or critical illness using NIH COVID‐19 Treatment Guidelines (https://www.covid19treatmentguidelines.nih.gov).
Calculated using two‐tailed chi‐squared test.
Denominator for spontaneous preterm birth rate excludes medically indicated preterm births.
Denominator for medically indicated preterm birth rate excludes spontaneous preterm births.