Table 2.

Naranjo Adverse Drug Reaction Probability Scale ¹ : the reaction is considered definite if the score is ≥ 9, probable if 5 to 8, possible if 1 to 4, and doubtful if 0 or less.

Question:		Patient
		1	2	3	4	5
1	Are there previous conclusive reports on this reaction? Yes: +1; No: 0; Don’t know: 0	0	0	+1	0	+1
2	Did the adverse event appear after the suspected drug was administered? Yes: +2; No: −1; Don’t know: 0	+2	+2	+2	+2	+2
3	Did the adverse reaction improve when the drug was discontinued, or a specific antagonist was administered? Yes: +1; No: 0; Don’t know: 0	+1	+2	+1	+1	+1
4	Did the adverse event reappear when the drug was re‐administered? Yes: +2; No: −1; Don’t know: 0	0	0	0	0	−1
5	Are there alternative causes that could on their own have caused the reaction? Yes: −1; No: +2; Don’t know: 0	+2	+2	+2	+2	+2
6	Did the reaction reappear when a placebo was given? Yes: −1; No: +1; Don’t know: 0	0	0	0	0	0
7	Was the drug detected in blood (or other fluids) in concentrations known to be toxic? Yes: +1; No: 0; Don’t know: 0	0	0	0	0	0
8	Was the reaction more severe when the dose was increased or less severe when the dose was decreased? Yes: +1; No: 0; Don’t know: 0	0	0	0	0	0
9	Did the patient have a similar reaction to the same or similar drugs in any previous exposure? Yes: +1; No: 0; Don’t know: 0	0	0	0	0	0
10	Was the adverse event confirmed by any objective evidence? Yes: +1; No: 0; Don’t know: 0	+1	+1	+1	+1	+1
	Total score	6	7	7	6	6