FIGURE 3.

Tubulin polymerization inhibitory activity of 7m in vitro. Polymerization of tubulin at 37°C, in the presence of 1% DMSO, compound 7m (5, 10, and 20 µM), and colchicine (10 µM), was measured by monitoring the excitation at 335 nm and emission at 460 nm. Data are presented as the mean ± SD from three independent experiments. **p < 0.01 vs. the vehicle control.