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. 2021 Nov 19;9:766201. doi: 10.3389/fchem.2021.766201

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Copyright © 2021 Sun, Wang, Yuan, Zhao, Zhang, Yao and Duan.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The compound 7m induces MCF-7 cell apoptosis. (A) Apoptosis ratio detection by Annexin/PI double staining assay through flow cytometry analysis treated with indicated concentrations of compound 7m for 48 h. (B) The quantitative analysis of apoptotic rate at early and advanced stages of MCF-cells. (C) Western blot analysis of the apoptosis-related proteins. (D) The quantitative analysis of the protein levels. The data are presented as the mean ± SD of three independent tests.