TABLE 2.
Evaluation of in vitro antiproliferative activity of α-methyl chalcones (7) and α-nitrile chalcones (8) (IC50 a ).
| Compound | IC50 ± SD (µM) | ||
|---|---|---|---|
| U937 | MCF7 | HepG2 | |
| 7b | 3.084 ± 0.433 | 0.584 ± 0.016 | 10.780 ± 0.629 |
| 7e | >20 | >20 | >20 |
| 7f | 1.615 ± 0.190 | 13.740 ± 0.965 | 0.193 ± 0.001 |
| 7h | 0.224 ± 0.007 | 0.254 ± 0.010 | 0.116 ± 0.007 |
| 7i | 1.176 ± 0.037 | 1.406 ± 0.021 | 0.879 ± 0.007 |
| 7m | 0.082 ± 0.002 | 0.1833 ± 0.032 | 0.070 ± 0.001 |
| 7n | 0.011 ± 0.002 | 0.020 ± 0.002 | 0.002 ± 0.0001 |
| 7o | 0.166 ± 0.003 | 0.187 ± 0.003 | 0.116 ± 0.001 |
| 7s | 0.353 ± 0.006 | 0.2247 ± 0.005 | 0.259 ± 0.005 |
| 8a | 0.140 ± 0.041 | 0.934 ± 0.023 | 0.938 ± 0.008 |
| 8b | >20 | >20 | >20 |
| 8c | 4.492 ± 0.433 | 2.096 ± 0.270 | 14.08 ± 0.386 |
| 8d | 8.584 ± 0.178 | >20 | >20 |
| 8e | >20 | >20 | >20 |
| 8f | >20 | >20 | >20 |
| 8g | 2.508 ± 0.029 | 2.161 ± 0.009 | 1.426 ± 0.049 |
| 8h | >20 | >20 | >20 |
| 8i | >20 | >20 | >20 |
| 8j | >20 | >20 | >20 |
| 8k | 14.313 ± 0.127 | 16.43 ± 0.042 | 18.742 ± 0.035 |
| 8l | >20 | >20 | >20 |
| 8m | >20 | >20 | >20 |
| 8n | 9.253 ± 0.141 | >20 | >20 |
| 8o | >20 | 14.74 ± 0.141 | 1.701 ± 0.013 |
| 8p | >20 | >20 | >20 |
| 8q | 52.322 ± 3.655 | >20 | >20 |
| 8r | 24.917 ± 2.015 | >20 | >20 |
| 8s | >20 | >20 | >20 |
| 8t | >20 | >20 | >20 |
| CA-4 | 0.0003 ± 0.0001 | 0.0114 ± 0.0002 | 0.0071 ± 0.0009 |
a
Note. Each compound was tested in triplicate; the data are presented as the mean ± SD.