TABLE 2.
Patients with a History of Hypersensitivity Reactions to Paclitaxel or Docetaxel with Positive Skin Testing or Reaction to COVID‐19 Vaccination
| ID | Age | Sex | Other drug/vaccine allergy history | Reaction to paclitaxel/docetaxel | COVID−19 vaccine | |||||
|---|---|---|---|---|---|---|---|---|---|---|
| Drug | Onset | Reaction symptoms | Reaction treatment | Excipient skin testing results a | Manufacturer | Outcome | ||||
| 1 | 53 | F |
Influenza vaccine (vision changes, wheezing, shortness of breath) Ampicillin (hives) |
Paclitaxel | 15 mins | Shortness of breath, chest pain, loss of consciousness | Diphenhydramine, unspecified steroid | Positive to PEG b | Janssen | Tolerated |
| 2 | 51 | F |
Influenza vaccine (facial erythema, dizziness) Pertuzumab and trastuzumab (flushing, swelling, hives) Cefadroxil (itching) Clindamycin (itching, facial swelling, facial erythema, malaise, rhinorrhea, cough) |
Docetaxel | 5 mins | Flushing, diarrhea | Diphenhydramine, famotidine | Negative to PEG and polysorbate 80 | Pfizer‐BioNTech |
Dose 1: dizziness, lightheadedness, nausea, hives, itching, increase throat secretions, upper lip swelling, rash Treatment: cetirizine and loratadine Dose 2: dizziness, nausea, lip swelling, increased throat secretions, rash Treatment: cetirizine |
| 3 | 66 | F |
Tetracycline (shortness of breath) Meperidine (vomiting) Nitrofurantoin (shortness of breath, cough) |
Paclitaxel | 4–6 h | Flushing, facial edema | Diphenhydramine | Negative to PEG | Janssen |
Flushing, facial swelling Treatment: diphenhydramine |